Sorbitan Monolaurate 20 as a Potential Skin Permeation Enhancer in Transdermal Patches
نویسنده
چکیده
The objective of our present work was to prepare transdermal matrix patches containing the drug, diclofenac diethylamine with various polymeric combinations of polyvinylpyrrolidone and ethylcellulose and to study the mechanism of release of the drug from the patches and its skin permeation. Sorbitan monolaurate 20 (Span 20), a non-ionic surfactant was added to the concentrations (0.1% wt/vol), as a skin permeation enhancer to the drug, diclofenac diethylamine. In vitro skin permeation studies, with rat skin, using a modified Keshary-Chien diffusion cell, were carried out to establish the most favorable polymeric combination and the impact of Span 20 was also studied. Extensive electron microscopy studies were conducted and the underlying mechanism of drug release from the patches and its permeation through skin are discussed. Cumulative amounts of drug released, per cm2 of patch after 48 hours, were found to be 2.6111 mg, 3.53 Mukhergee-vol5no1 3/8/05 4:14 PM Page 96
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